Abstract
Experimental diabetes induced by total pancreatectomy has a more severe course than
the streptozotocin-diabetes produced with 100 or 120 mg/kg or less. Pancreatectomy
is accompanied by a high loss of animals (30%). Streptozotocin-diabetes is more suitable
for transplantation experiments because: firstly, the animals show glycosuria within
24 hours; secondly, the development of diabetes can be influenced by various doses
of streptozotocin. However, pancreatectomy makes it easier to discern whether transplanted
islets secrete insulin or whether measured hormone is secreted by the body's own pancreatic
tissue.
Key words
Experimental Diabetes - Pancreatectomy - Streptozotocin - Glycosuria - I.V. Glucose-Tolerance
Test - Cataract - Survival-Rate
1 Institute "Rudjer Bošković", Zagreb, Yugoslavia
2 Supported by Deutsche Forschungsgemeinschaft (SFB 87, Grant J, 16, Ulm)
